Design, Synthesis, and Structure–Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors

…, P Sirajuddin, K Peltonen, M DePasquale…

文献索引：Colis, Laureen; Ernst, Glen; Sanders, Sara; Liu, Hester; Sirajuddin, Paul; Peltonen, Karita; Depasquale, Michael; Barrow, James C.; Laiho, Marikki Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4950 - 4961

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被引用次数: 3

摘要

RNA polymerase I (Pol I) is a dedicated polymerase that transcribes the 45S ribosomal (r) RNA precursor. The 45S rRNA precursor is subsequently processed into the mature 5.8 S, 18S, and 28S rRNAs and assembled into ribosomes in the nucleolus. Pol I activity is ...