Total synthesis of 3, 17β-dihydroxy-6-oxaestra-1, 3, 5 (10), 7-tetraen and related miroestrol analogues

JA Findlay, P Mebe, MD Stern…

文献索引：Findlay; Mebe; Stern; Givner Canadian Journal of Chemistry, 1980 , vol. 58, # 14 p. 1427 - 1434

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被引用次数: 11

摘要

3, 17β-Dihydroxy-6-oxaestra-1, 3, 5 (10), 7-tetraen and related steroidal compounds have been synthesized in high yield via condensation of 7-methoxy-4-vinyl coumarin and 2- methyl-1, 3-pentanedione. The approximate uterotrophic activity of the synthetic compounds relative to 17β-estradiol has been determined.