3, 17β-Dihydroxy-6-oxaestra-1, 3, 5 (10), 7-tetraen and related steroidal compounds have been synthesized in high yield via condensation of 7-methoxy-4-vinyl coumarin and 2- methyl-1, 3-pentanedione. The approximate uterotrophic activity of the synthetic compounds relative to 17β-estradiol has been determined.
