Multi??Step Synthesis and Biological Evaluation of Analogues of Insulin Secretagogue (2S, 3R, 4S)??4??Hydroxyisoleucine

K Aouadi, AD Lajoix, R Gross…

文献索引：Aouadi, Kaiss; Lajoix, Anne-Dominique; Gross, Rene; Praly, Jean-Pierre European Journal of Organic Chemistry, 2009 , # 1 p. 61 - 71

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被引用次数: 3

摘要

Abstract A series of stereochemically defined analogues of (2S, 3R, 4S)-4-hydroxyisoleucine and related α-hydroxy acids have been prepared by multi-step routes from D-glucose, whereas ketolization between TBDMS-protected hydroxypropanone and ethyl isocyanoacetate led to racemic analogues. Bioassays showed that of eight newly synthesized compounds, two of them presented an interesting statistical trend to increase ...