1 soluble, was readily separable from the peptide products. The lengthy synthesis of 1 was merely outlined by these workers. In general, the literature concerning isoxazolium salts is scant. Pertinent references include those cited by Woodward and Ol~ fson;~ in addition Lampe and Smolinska4 have described the alkylation of 3, 5-disubstituted isoxazoles. Our interest in these salts has led to an elaboration of the synthesis of 1 and an extension to ...
