Ferrocene tripeptide Gly-Pro-Arg conjugates: Synthesis and inhibitory effects on Alzheimer's Aβ 1–42 fibrillogenesis and Aβ-induced cytotoxicity in vitro

B Zhou, CL Li, YQ Hao, MC Johnny, YN Liu…

文献索引：Zhou, Binbin; Li, Chun-Lan; Hao, Yuan-Qiang; Johnny, Muya Chabu; Liu, You-Nian; Li, Juan Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 395 - 402

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被引用次数: 8

摘要

Alzheimer's disease (AD) is the most common cause of dementia, and currently there is no clinical treatment to cure it or to halt its progression. Aggregation and fibril formation of β- amyloid peptides (Aβ) are central events in the pathogenesis of AD. Many efforts have been spent on the development of effective inhibitors to prevent Aβ fibrillogenesis and cause disaggregation of preformed Aβ fibrils. In this study, the conjugates of ferrocene and Gly- ...