Synthesis and anti-parasitic activity of a novel quinolinone–chalcone series

…, SC Lima, AC da Silva, S Wilkinson, A Detsi

文献索引：Roussaki, Marina; Hall, Belinda; Lima, Sofia Costa; Da Silva, Anabela Cordeiro; Wilkinson, Shane; Detsi, Anastasia Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6436 - 6441

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被引用次数: 13

摘要

Abstract A series of novel quinolinone–chalcone hybrids and analogues were designed, synthesized and their biological activity against the mammalian stages of Trypanosoma brucei and Leishmania infantum evaluated. Promising molecular scaffolds with significant microbicidal activity and low cytotoxicity were identified. Quinolinone–chalcone 10 exhibited anti-parasitic properties against both organisms, being the most potent anti-L. infantum ...