Synthetic Communications®

Convenient and Efficient Preparation of Ethyl 6-n-Decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate

M Xu, J Zhang, X Wu, J Sun, Z Shi

文献索引：Xu, Maoyou; Zhang, Jin; Wu, Xue; Sun, Juanjuan; Shi, Zhiqiang Synthetic Communications, 2010 , vol. 40, # 7 p. 992 - 997

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被引用次数: 1

摘要

Ethyl 6-n-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate has the most reactivity of decoquinate anticoccidial drugs. [ 1-6 View all references ] It is usually synthesized through 4-n-decyloxy-3 -ethoxyaniline and ethoxymethylene malonic diethyl ester (EMME) reaction. [ 7-11 View all references ] Generally, the intermediate 4-n-decyloxy-3-ethoxyaniline was synthesized by reducing the 1-(decyloxy)-2-ethoxy-4-nitrobenzene [ 12-14 View all references ] or the corresponding ...