Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity

…, J Stolaříková, J Mandíková, F Trejtnar, V Buchta

文献索引：Vinsova, Jarmila; Kozic, Jan; Kratky, Martin; Stolarikova, Jirina; Mandikova, Jana; Trejtnar, Frantisek; Buchta, Vladimir Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 728 - 737

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被引用次数: 11

摘要

Abstract A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on- going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5–62.5 μmol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the ...