Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure–activity relationship

…, L Bi, W Bi, Z Li, M Zhao, C Wang, J Ju, S Peng

文献索引：Wu, Yihui; Bi, Lanrong; Bi, Wei; Li, Zeng; Zhao, Ming; Wang, Chao; Ju, Jingfang; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5711 - 5720

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被引用次数: 35

摘要

To develop more potent small molecules with enhanced free radical scavenger properties, we designed and synthesized a series of nitronyl nitroxide derivatives 4a–h. A lead compound 4f was discovered based on Ach-induced vascorelaxation assay. Further chemical modification based on this scaffold provided a new series of 2-substituted phenylnitronyl nitroxide derivatives 6a–s. The newly synthesized compounds 6a–s ...