Molecules

New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities

…, A Pabón, S Pérez-Silanes, S Galiano, G Gonzalez…

文献索引：Barea, Carlos; Pabon, Adriana; Perez-Silanes, Silvia; Galiano, Silvia; Gonzalez, German; Monge, Antonio; Deharo, Eric; Aldana, Ignacio Molecules, 2013 , vol. 18, # 4 p. 4718 - 4727

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被引用次数: 16

摘要

Abstract: Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1, 4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their ...