Synthesis of novel benzamidine-and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

…, C Ebikeme, MP Barrett, EM Patzewitz, S Müller…

文献索引：Reid, Caroline M.; Ebikeme, Charles; Barrett, Michael P.; Patzewitz, Eva-Maria; Mueller, Sylke; Robins, David J.; Sutherland, Andrew Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5399 - 5401

全文：HTML全文

被引用次数: 12

摘要

Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti- protozoal activity against trypanosomes.