Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors

…, S Koul, MV Reddy, N Thota, IA Khan, A Kumar…

文献索引：Sangwan, Payare L.; Koul, Jawahir L.; Koul, Surrinder; Reddy, Mallepally V.; Thota, Niranjan; Khan, Inshad A.; Kumar, Ashwani; Kalia, Nitin P.; Qazi, Ghulam N. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9847 - 9857

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被引用次数: 56

摘要

Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor (EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid and verapamil. The inhibitory mechanism of the compounds was confirmed by efflux inhibition assay using ethidium bromide as NorA ...