Journal of the American Chemical Society

Atom-Economical Synthesis of N-Heterocycles via Cascade Inter-/Intramolecular C− N Bond-Forming Reactions Catalyzed by Ti Amides

H Shen, Z Xie

文献索引：Shen, Hao; Xie, Zuowei Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11473 - 11480

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被引用次数: 44

摘要

Direct and efficient catalytic reactions with excellent regioselectivity for the preparation of a series of substituted isoindoles, isoquinolines, and imidazoles are reported. Reaction of C6H4 (2-CN) C CR with an array of amines, catalyzed by 10 mol% of [σ: η1: η5- (OCH2)(Me2NCH2) C2B9H9] Ti (NMe2)(1), gives a series of substituted isoindoles in very high yields. In a similar manner, interaction of C6H4 (2-CH2CN) C C-Ph with various ...