Chemistry Letters

Protection of the tryptophan indole ring in peptide synthesis. Use of a new derivative, Nin-2, 2, 2-trichloroethoxycarbonyltryptophan.

Y Kiso, M Inai, K Kitagawa, T Akita

文献索引：Kiso, Yoshiaki; Inai, Masatoshi; Kitagawa, Kouki; Akita, Tadashi Chemistry Letters, 1983 , p. 739 - 742

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被引用次数: 7

摘要

The 2, 2, 2-trichloroethoxycarbonyl (Troc) group attached at the N in function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-n-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, eg, hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.