Anxiolytic properties of certain annelated [1, 2, 4] triazolo [1, 5-c] pyrimidin-5 (6H)-ones

…, JL Hyun, SL Rovinski, CL Amrick, PS Loo…

文献索引：Francis; Bennett; Hyun; Rovinski; Amrick; Loo; Murphy; Neale; Wilson Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2899 - 2906

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被引用次数: 16

摘要

One of these, 9-benzyl-2-phenyl-7, 8, 9, 10-tetrahydropyrido [3, 4-e][1, 2, 4] triazolo [1, 5-c] pyrimidin-5 (6H)-one, showed good activity in rats as a potential anxiolytic agent without sedative liability. However, it increased the rotorod deficit produced by ethanol at anxiolytic doses, an indication of alcohol interaction. Thus, none of the compounds showed an advantage over CGS 9896 (Yokoyama et al. J. Med. Chem. 1982, 25,337-339), which is ...