Ether aryl sulfonic acid esters with improved antimalarial/anticancer activities

…, NC Tam, SMH Kabir, RF Langler, I Crandall

文献索引：Betts, Lynn M.; Tam, Nga Chiu; Kabir, S. M. Humayun; Langler, Richard F.; Crandall, Ian Australian Journal of Chemistry, 2006 , vol. 59, # 4 p. 277 - 282

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被引用次数: 13

摘要

Abstract Our previous report showed that our current benchmark agent, 4-methoxyphenyl p- toluenesulfonate, is a selective antimalarial/anticancer agent. A series of related sulfones and sulfonic acid esters is now examined. 4-Allyloxyphenyl p-toluenesulfonate is a superior antimalarial/anticancer agent. 4-Methoxyphenyl 4-nitrobenzenesulfonate is a superior antimalarial agent, but shows poorer inhibition of human skin cancer cells.