Tetrahedron Letters

N-Acyl imine and enamide intermediates in the palladium-catalyzed amidocarbonylation reaction

DA Freed, MC Kozlowski

文献索引：Freed, Dana A.; Kozlowski, Marisa C. Tetrahedron Letters, 2001 , vol. 42, # 20 p. 3403 - 3406

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被引用次数: 9

摘要

N-Acyl imines and enamides have been synthesized and subjected to the reaction conditions for palladium-catalyzed amidocarbonylation of aldehydes. These compounds were competent substrates resulting in the formation of N-acyl amino acids; however, the presence of water was found to be necessary. Direct study of the same amidocarbonylation reaction revealed that enamides could be detected during the course of the reaction. A ...