Anatoxin-a (s), a potent anticholinesterase from Anabaena flos-aquae

S Matsunaga, RE Moore, WP Niemczura…

文献索引：Matsunaga, Shigeki; Moore, Richard E.; Niemczura, Walter P.; Carmichael, Wayne W. Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 8021 - 8023

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被引用次数: 199

摘要

Anatoxin-a (s) is a neurotoxic alkaloid associated with the blue-green alga Anabaena flos- aquae.'It potent toxicity (LDSo 20-40 bg/kg mice) is attributed to exceptional anticholinesterase activity. 2 We report here the isolation of anatoxin-a (s) from a cultured strain NRC 525-17 and a field-collected bloom implicated in animal poisonings3 and the determination of its structure as