Synthesis and structure-activity studies of a series of [(hydroxybenzyl) amino] salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity

…, J Boiziau, F Parker, R Maroun, B Tocque…

文献索引：Chen, Huixiong; Boiziau, Janine; Parker, Fabienne; Maroun, Rachid; Tocque, Bruno; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4094 - 4098

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被引用次数: 32

摘要

The synthesis and structureactivity relationships of a series of [(hydroxybenzylidene) amino]- salicylates and a series of [(hydroxybenzyl) aminolsalicylateg as inhibitors of EGF receptor- associated tyrosine kinase activity are described. Their inhibitory potency was evaluated in vitro using ER 22 cell membranes (CCL 39 cells transfected with EGF receptor) as an enzyme source and the tridecapeptide RRSrc (RRLIEDAEYAARG) as substrate. Their ...