Tetrahedron Letters

Convenient and rapid synthesis of α-aminonitriles starting directly from nitro compounds in water

B Das, G Satyalakshmi, K Suneel

文献索引：Das, Biswanath; Satyalakshmi, Gandham; Suneel, Kanaparthy Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2770 - 2773

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被引用次数: 8

摘要

A distinct approach for the synthesis of α-aminonitriles has been discovered by three- component reaction of nitroarenes, aldehydes, and TMSCN using indium in dilute aqueous HCl at room temperature. The products were formed in high yields (86–96%) within a short period of time (5–20min). This one-pot conversion consists of the following steps:(i) reduction of nitro compounds to amines,(ii) formation of imines from amines and ...