Journal of medicinal chemistry

Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata

RE Betts, DE Walters, JP Rosazza

文献索引：Betts,R.E. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 599 - 602

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被引用次数: 112

摘要

Microbial transformations have been employed as a method for producing quantities of a potentially active metabolite of the antitumor alkaloid acronycine. More than 40 microorganisms were screened for their abilities to convert acronycine to metabolites in small-scale fermentations. Ten cultures were found to accumulate one or more acronycine derivatives in culture media. In larger scale fermentations, Cunninghamella echinulata ( ...