Convenient Approaches to 4-Trifluoromethylpyridine

B Jiang, W Xiong, X Zhang, F Zhang

文献索引：Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534

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被引用次数: 14

摘要

A number of approaches to the synthesis of 2-chloro-and 2, 6-dichloro-4- trifluoromethylpyridine are described. The first method for 2-chloro-and 2, 6-dichloro-4- trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2, 6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl ( ...