Canadian Journal of Chemistry

ANTINEOPLASTIC AGENTS: X. N-BIS (2-FLUOROETHYL) AMINES

GR Pettit, RL Smith

文献索引：Pettit,G.R.; Smith,R.L. Canadian Journal of Chemistry, 1964 , vol. 42, p. 572 - 578

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被引用次数: 15

摘要

Successive conversion of N-bis (2-hydroxyethyl)-p-toluenesulphonamide (I b) to respective dimethanesulphonate and difluoro derivatives (II a, III a, and III c) was found to provide a convenient route to N-bis (2-fluoroethyl) amine. Reaction of N-bis (2-methanesulphonyl- oxyethyl)-p-toluenesulphonamide (III a) with limited quantities of potassium fluoride, in several pro tic solvents, was shown to yield N-(p-toluenesulphonyl) morpholine (IV). Utility ...