Synthesis and anti-cancer activity of C-ring-functionalized prodigiosin analogues

…, A Al-Sheikh Ali, A Thompson

文献索引：Regourd, Jasmine; Ali, Adeeb Al-Sheikh; Thompson, Alison Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1528 - 1536

全文：HTML全文

被引用次数: 59

摘要

Prodigiosin is the parent member of the 4-methoxypyrrolyldipyrromethene family of natural products and is known for its anti-cancer activity. A new series of analogues was synthesized, incorporating pendent functional esters and β-carbonyl substituents on the C- ring. The β-carbonyl group allowed for the facile isolation of the prodigiosenes, and the pendent esters allow for further derivatization. The novel prodigiosenes generally retain ...