Design and synthesis of novel 3-substituted-indole derivatives as selective H 3 receptor antagonists and potent free radical scavengers

…, F Yang, R Sheng, J Chen, Y Shi, N Zhou, Y Hu

文献索引：Tang, Li; Zhao, Liying; Hong, Lingjuan; Yang, Fenyan; Sheng, Rong; Chen, Jianzhong; Shi, Ying; Zhou, Naimin; Hu, Yongzhou Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 5936 - 5944

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被引用次数: 7

摘要

Abstract A series of novel 3-substituted-indole derivatives with a benzyl tertiary amino moiety were designed, synthesized and evaluated as H 3 receptor antagonists and free radical scavengers for Alzheimer's disease therapy. Most of these synthesized compounds exhibited moderate to potent antagonistic activities in CREs driven luciferase assay. In particular, compound 2d demonstrated the most favorable H 3 receptor antagonistic ...