Synthesis and evaluation of quinonoid compounds against tumor cell lines

…, TT Guimarães, FR Maria do Carmo, IO Cabral…

文献索引：Da Silva Jr., Eufranio N.; Cavalcanti, Bruno C.; Guimaraes, Tiago T.; Pinto, Maria Do Carmo F.R.; Cabral, Igor O.; Pessoa, Claudia; Costa-Lotufo, Leticia V.; De Moraes, Manoel O.; De Andrade, Carlos K.Z.; Dos Santos, Marcelo R.; De Simone, Carlos A.; Goulart, Marilia O.F.; Pinto, Antonio V. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 399 - 410

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被引用次数: 52

摘要

Thirty two compounds were synthesized in moderate to high yields and showed activity against cancer cells HL-60 (leukemia), MDA-MB435 (melanoma), HCT-8 (colon) and SF295 (central nervous system), with IC50 below 2 μM for some compounds. The β-lapachone- based 1, 2, 3-triazoles showed the best cytoxicity profile and emerge as promising anticancer prototypes. Insights about the reactive oxygen species (ROS) mechanism of ...