Parallel synthesis and biological activity of a new class of high affinity and selective δ-opioid ligand

…, J Cottney, K McGurk, JR Morphy, Z Rankovic…

文献索引：Barn; Caulfield; Cottney; McGurk; Morphy; Rankovic; Roberts Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2609 - 2624

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被引用次数: 21

摘要

A considerable number of research papers describing the synthesis and testing of the delta opioid receptor (DOR) ligands, SNC-80 and TAN-67, and analogues of these two compounds, have been published in recent years. However, there have been few reports of the discovery of completely new structural classes of selective DOR ligand. By optimising a hit compound identified by high throughput screening, a new series of ...