Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4??(4??fluorobenzyl) piperidine

…, B Agai, G Tárkányi, L Vida, F Faigl

文献索引：Proszenyak, Agnes; Agai, Bela; Tarkanyi, Gabor; Vida, Laszlo; Faigl, Ferenc Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 6 p. 421 - 427

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被引用次数: 7

摘要

Abstract Pure 4-(4-fluoro-[2, 3, 5, 6-2 H 4] benzyl) piperidine was prepared via the Grignard reaction of 4-fluoro-[2, 3, 5, 6-2 H 4] bromobenzene and pyridine-4-aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4-(4-fluorobenzyl) piperidine and its d 4 derivative has also been described. Copyright© ...