Structural aspects of nucleation inhibitors for diastereomeric resolutions and the relationship to Dutch Resolution

…, E Gelens, T Vries, B Kaptein, R Kellogg

文献索引：Leeman, Michel; Brasile, Giuseppina; Gelens, Edith; Vries, Ton; Kaptein, Bernard; Kellogg, Richard Angewandte Chemie - International Edition, 2008 , vol. 47, # 7 p. 1287 - 1290

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被引用次数: 23

摘要

The resolution of enantiomers [1a, b] by Dutch Resolution [2] involves the use of an equimolar mixture of two or three structurally similar and homochiral [3] resolving agents. Two major factors contribute to the success of the method. First, the structurally similar resolving agents often form a nonstoichiometric solid solution of crystals.[4, 5] Second, one of the resolving agents can act as a nucleation inhibitor and retains the more soluble ...