Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity

…, FI Tarazi, RJ Baldessarini, JL Neumeyer

文献索引：Granchelli, Felix E.; Filer, Crist N.; Soloway, Albert H.; Neumeyer, John L. Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2275 - 2278

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被引用次数: 24

摘要

We developed a procedure to synthesize a series of N-alkyl-2-methoxy-11- hydroxynoraporphines from thebaine and evaluated their binding affinities at dopamine D1 and D2 receptors in rat forebrain tissue. At D2 receptors, the most potent 10, 11-catechol-