Organic letters

A Facile and Efficient Synthesis of Polyfunctionalized Pyridin-2 (1 H)-ones from β-Oxo Amides under Vilsmeier Conditions

D Xiang, K Wang, Y Liang, G Zhou, D Dong

文献索引：Xiang, Dexuan; Wang, Kewei; Liang, Yongjiu; Zhou, Guangyuan; Dong, Dewen Organic Letters, 2008 , vol. 10, # 2 p. 345 - 348

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被引用次数: 58

摘要

A facile and efficient one-pot synthesis of polysubstituted pyridin-2 (1 H)-ones from a variety of β-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.