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Journal of Organic Chemistry

Synthesis of myosmine and nornicotine, using an acylcarbanion equivalent as an intermediate

E Leete, MR Chedekel, GB Bodem

文献索引:Leete,E. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 4465 - 4466

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被引用次数: 43

摘要

~~-Morpholino-~ r-(3-pyridyl) acetonitrile (2).-Pyridine-3-aldehyde (Aldrich Chemical Co.)(6.96 g) was added to a solution of morpholine perchlorate (13.3 g) in morpholine (64 ml) and the mixture wab heated at 80" for 1 hr. Potassium cyanide (4.5 g), dissolved in a minimum amount of water, was added and the mixture was heated at 1GO0 for an additional hour. The cooled reaction mixture was added to aqueous potassium carbonate (10%) and ...