Bulletin of the Chemical Society of Japan

Syntheses of N-acyl dipeptide derivatives by metalloproteinases.

Y Isowa, T Ichikawa

文献索引：Isowa,Y.; Ichikawa,T. Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 796 - 800

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被引用次数: 33

摘要

X–Dipeptides (X= Z, Z (OMe), or Z (3Me)) have been catalytically synthesized by several microbial metalloproteinases. Among the enzymes used, Thermolysin showed the most remarkable ability in the coupling reactions of the esters or the amides of phenylalanine, leucine, isoleucine, and valine (and methionine in the case of the amide) with various X– amino acids. This method has been applied to the syntheses of ZPhePheOMe and ...