Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2

…, DJ Rieman, PE Bender, B Ferguson…

文献索引：Kruse; Holden; Offen; Pritchard; Feild; Rieman; Bender; Ferguson; Greig; Poste Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1768 - 1772

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被引用次数: 22

摘要

Tyrosine-specific protein kinases that transfer the terminal phosphate from ATP to protein acceptors are associated with certain transforming viruses and cell surface growth factor receptors. Here we describe the synthesis and testing of potential multisubstrate inhibitors of this class of enzymes. The inhibitors were prepared by covalent attachment of the terminal phosphate of ATP or its tetraphosphate analogue to tyrosine mimics. Testing against p60U ...