Lancini, et al., 4 who described a synthesis used to prepare the D, L, and DL forms of the compound. Their approach was based upon the exothermic conversion of the p- chloroalanine derivative DL-I1 to DL-2-amino-3-(hydroxyamino)-propionic acid (DL-111) by means of hydroxylamine in the absence of solvent. Resolution of N, N'-dibenzoyl-DL-111 by way of its cinchonine salt gave D-I11 and L-I11 upon removai of the blocking groups. This ...
