Synthesis

An efficient, highly enantioenriched route to L-carnitine and α-lipoic acid via hydrolytic kinetic resolution

DS Bose, L Fatima, S Rajender

文献索引：Bose, D. Subhas; Fatima, Liyakat; Rajender, Salla Synthesis, 2006 , # 11 p. 1863 - 1867

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被引用次数: 2

摘要

Abstract A general and practical approach for the synthesis of C-4 chiral building blocks using Jacobsen's hydrolytic kinetic resolution technique to resolve terminal epoxides and diols in high enantiomeric excess and excellent yields is described. The utilization of these building blocks for the synthesis of biologically important natural products l-carnitine and α- lipoic acid is illustrated.