Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK

T Ozawa, H Kitagawa, Y Yamamoto, S Takahata…

文献索引：Ozawa, Tomohiro; Kitagawa, Hideo; Yamamoto, Yasuo; Takahata, Sho; Iida, Maiko; Osaki, Yumi; Yamada, Keiko Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 23 p. 7325 - 7336

全文：HTML全文

被引用次数: 8

摘要

Bacterial enoyl-acyl carrier protein (ACP) reductases (FabI and FabK) catalyze the final step in each cycle of bacterial fatty acid biosynthesis and are attractive targets for the development of new antibacterial agents. Here, we report the development of novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae. Based on structure– activity relationship (SAR) studies of our screening hits, we have developed novel ...