Tetrahedron Letters

Dehydrative synthesis of chiral oxazolidinones catalyzed by alkali metal carbonates under low pressure of CO 2

SW Foo, Y Takada, Y Yamazaki, S Saito

文献索引：Foo, Siong Wan; Takada, Yuki; Yamazaki, Yusuke; Saito, Susumu Tetrahedron Letters, 2013 , vol. 54, # 35 p. 4717 - 4720

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被引用次数: 11

摘要

Abstract Dehydrative synthesis of oxazolidinones from amino alcohols and CO 2 was achieved in the presence of alkali metal carbonates such as Cs 2 CO 3 as catalyst. It is noteworthy that 1 atm of CO 2 is enough for the reaction to proceed and no special dehydrating agent is required in this system. A mechanstic study showed that the OH of amino alcohol acts as nucleophile and the OH in the carbamic acid moiety is liberated ...