A straightforward synthesis of pyrimido [4, 5-b] quinoline derivatives assisted by microwave irradiation

…, J Trilleras, B Insuasty, R Abonía, M Nogueras…

文献索引：Quiroga, Jairo; Trilleras, Jorge; Insuasty, Braulio; Abonia, Rodrigo; Nogueras, Manuel; Marchal, Antonio; Cobo, Justo Tetrahedron Letters, 2010 , vol. 51, # 7 p. 1107 - 1109

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被引用次数: 25

摘要

Several pyrimido [4, 5-b] quinolines, flavin analogues, have been prepared by assisted microwave intramolecular cyclization of N4-substituted-2, 4-diamino-6-chloropyrimidine-5- carbaldehydes. The reaction takes place with hydrolysis of amino-group and chlorine. Particularly valuable features of this method included the broader substrate scope and operational simplicity as well as increased safety for small-scale high-speed synthesis.