Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives

JL Santos, PR Yamasaki, CM Chin, CH Takashi…

文献索引：Santos, Jean L.; Yamasaki, Paulo R.; Chin, Chung Man; Takashi, Celio H.; Pavan, Fernando R.; Leite, Clarice Q.F. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 11 p. 3795 - 3799

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被引用次数: 49

摘要

New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70–90%). All compounds (3a–l) were evaluated against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 μg/mL, respectively, and could be considered new lead compounds in the treatment of ...