Synthesis and biological evaluation of certain C-4 substituted pyrazolo [3, 4-b] pyridine nucleosides

…, RC Willis, RK Robins, GR Revankar

文献索引：Sanghvi; Larson; Willis; Robins; Revankar Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 945 - 951

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被引用次数: 54

摘要

A series of C-4 substituted pyrazolo [3,441 pyridine nucleosides have been synthesized and evaluated for their biological activity. Successful synthesis of various C-4 substituted pyrazolo [3, 4-b] pyridine nucleosides involves nucleophilic displacement by a suitable nucleophile at the C-4 position of 4-chloro-1H-pyrazolo [3, 4-b] pyridine(9, followed by glycosylation of the sodium salt of the C-4 substituted pyrazolo [3, 4-b] pyridines with a ...