The enzymatic synthesis of isotopically labelled penicillin Ns with isopenicillin N synthase
JE Baldwin, RM Adlington, NP Crouch…
文献索引：Baldwin, Jack E.; Adlington, Robert M.; Crouch, Nicholas P.; Pereira, Ines A.C. Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 12 p. 1145 - 1163
Abstract The preparation of isotopically labelled penicillin Ns using a chemico-enzymatic approach is described. This route involves the chemical synthesis of variously labelled D, L, D-aminoadipoyl-cysteinyl-valine tripeptides via well established facile protocols and concludes with the conversion of these tripeptides directly into penicillin Ns by the action of recombinant isopenicillin N synthase. Milligram quantities of isotopically labelled penicillin ...
