An efficient and regioselective N-alkylation of 4 (3H)-pyrimidone with various electrophiles in the presence of Fe nano particle is reported. The catalyst initiates N-alkylation of amides by alkyl chlorides. The reaction of equimolar 4 (3H)-pyrimidone and 2-chloro-3-(chloromethyl) quinolines in the presence of KOH and Fe nano particle (5mol%) in DMSO solution under reflux condition formed 3-[(2-chloroquinolin-3-yl] methyl) pyrimidin-4 (3H) ones.
