Studies of the tautomerism of purine and the protonation of purine, and its 7-and 9-methyl derivatives, by nitrogen-15 nuclear magnetic resonance spectroscopy

NC Gonnella, JD Roberts

文献索引：Gonnella, Nina C.; Roberts, John D. Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3162 - 3164

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被引用次数: 81

摘要

Abstract: The nitrogen-I5 NMR shifts of purine and its 7-and 9-methyl derivatives were measured at the natural-abundance level as a function of pH. The results made it possible for both the sites and magnitudes of protonation of purine and its derivatives to be determined. A semiquantitative determination was made of the position of the N7H-N9H tautomeric equilibria of purine in both water and dimethyl sulfoxide.