Correlation between lipophilicity and reactivity under biomimetic conditions of β-hydroxybarbiturates

O LaFont, J Chastang, C Cavé, M Miocque

文献索引：Lafont; Chastang; Cave; Miocque European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 283 - 289

全文：HTML全文

被引用次数: 1

摘要

Abstract The effects of lipophilicity are studied on a chemical equilibrium between β- hydroxybarbiturates and corresponding allophanoyl γ-lactones under biomimetic conditions, in order to show that this physicochemical parameter is not only active in vivo on drug disposition, but also on the kinetics of chemical reactions.