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Synthetic applications of difluorocarbene I. The preparation of some aryl difluoromethyl ethers, thioethers and sulphones

A De Cat, R Van Poucke, R Pollet…

文献索引:De Cat,A. et al. Bulletin des Societes Chimiques Belges, 1965 , vol. 74, p. 270 - 280

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被引用次数: 16

摘要

As an extension of the analogous synthesis of aryl difluoromethyl ethers, difluorocarbene. generated from the basic hydrolysis of chlorodifluoromethane in aqueous dioxane, is brought into reaction with thiophenols, yielding aryl difluoromethyl thioethers. Further conversions lead to the m- and p-difluoromethoxy-, difluoro- niethylthio- and difluoromethylsulphonyl-substituted benzoic acids. The chemical stability of the difluoro substituents is discussed and com- pared with ...