Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs
…, C Pender, C Penaranda, M Zavodovskaya…
文献索引：Blecha, Joseph E.; Anderson, Marc O.; Chow, Jennifer M.; Guevarra, Christle C.; Pender, Celia; Penaranda, Cristina; Zavodovskaya, Marianna; Youngren, Jack F.; Berkman, Clifford E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4026 - 4029
Herein, we pursue the hypothesis that the structure of nordihydroguaiaretic acid (NDGA) can be refined for selective potency against the insulin-like growth factor 1 receptor (IGF-1R) as a potential therapeutic target for breast cancer while diminishing its action against other cellular targets. Thus, a set of NDGA analogs (7a–7h) was prepared and examined for inhibitory potency against IGF-1R kinase and an alternative target, 15-lipoxygenase (15 ...
