Journal of Organometallic Chemistry

Metallation regioselective en serie pyridinique: Synthese originale d'amino-2 aroyl-3 pyridines

T Güngör, F Marsais, G Queguiner

文献索引：Guengoer, Timur; Marsais, Francis; Queguiner, Guy Journal of Organometallic Chemistry, 1981 , vol. 215, # 2 p. 139 - 150

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被引用次数: 43

摘要

Abstract Lithium diisopropylamide reacts with 2-fluoropyridine at low temperature: regioselectivity is excellent and metallation occurs without side reactions such as nucleophilic attack. 2-Fluoro-3-lithiopyridine is formed and with aldehydes it gives the corresponding fluorinated alcohols which are then selectively oxidized. Halogen substitution using amines leads to various 3-oxoalkyl-or 3-aroyl-2-aminopyridines.