Evaluation and Optimisation of the Reagent Addition Sequence during the Synthesis of Atrazine (6-Chloro-N 2-ethyl-N 4-isopropyl-1, 3, 5-triazine-2, 4-diamine) Using …
B Barton, S Gouws, MC Schaefer…
文献索引：Barton, Benita; Gouws, Shawn; Schaefer, Melissa C.; Zeelie, Bernard Organic Process Research and Development, 2003 , vol. 7, # 6 p. 1071 - 1076
The sequence of reagent addition and associated heats of reaction during the synthesis of the important herbicide atrazine (6-chloro-N 2-ethyl-N 4-isopropyl-1, 3, 5-triazine-2, 4- diamine) from cyanuric chloride, isopropylamine, and ethylamine have been investigated by means of calorimetric and analytical methods. Sodium hydroxide was used as proton scavenger in this procedure. The best addition sequence found was the concurrent ...
