Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)-thieno [3, 2-b] pyridin-7-yl]-(2- …

JA Ragan, JW Raggon, PD Hill, BP Jones…

文献索引：Organic Process Research and Development, , vol. 7, # 5 p. 676 - 683

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被引用次数: 35

摘要

... Organic Process Research & Development. ... reagent derived from 2-(tert-butyldimethylsilyl)-1- methylimidazole and iodothienopyridine (3). The latter procedure worked well ... Fortunately, both 2 and 1 are solids which crystallize to purge residual organic impurities quite efficiently. ...